gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 on target cells and kills them via Fc-mediated ADCC (NK cells), complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and can trigger direct apoptosis upon cross-linking.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NADase/ADP-ribosyl cyclase) expressed on malignant plasma cells and immunosuppressive immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05434689
disease_id_num_tar_ref
5459
drug_id_num_tar_ref
14828