gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated IgG1 binds IL-5Rα and engages FcγRIIIa on NK cells to induce strong ADCC, leading to apoptosis/depletion of IL-5Rα-expressing eosinophils and basophils.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alpha chain of IL-5 receptor (CD125) on eosinophils/basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06465485
disease_id_num_tar_ref
5485
drug_id_num_tar_ref
14925