gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils; its afucosylated Fc engages FcγRIIIa (CD16a) on NK cells to trigger ADCC that kills IL-5Rα+ cells. CD16a+ cells act as effectors and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement for ADCC; affinity enhanced by afucosylated IgG1 Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06465485
disease_id_num_tar_ref
5485
drug_id_num_tar_ref
14925