gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 via the CAR, activate through CD3ζ/costimulatory domains, and kill CD19+ cells via perforin–granzyme cytolysis (and Fas–FasL), independent of MHC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06796517
disease_id_num_tar_ref
5489
drug_id_num_tar_ref
14936