gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab targets CD20 on B cells; its afucosylated Fc engages Fcγ receptors (including CD16b) on effector cells to drive ADCC and also induces direct apoptosis of CD20+ B cells. CD16b-expressing cells are effector cells and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc region interaction; afucosylated Fc increases affinity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06796517
disease_id_num_tar_ref
5489
drug_id_num_tar_ref
14940