gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Ofatumumab binds CD20 on B cells, activates complement to induce membrane attack complex–mediated lysis (CDC) and engages Fcγ receptors on effector cells (e.g., NK cells, macrophages) to drive ADCC and phagocytosis, killing CD20+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen on B cells; Ofatumumab binds extracellular loops
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06867991
disease_id_num_tar_ref
5492
drug_id_num_tar_ref
14947