gene_symbol
TNFRSF13C
hgnc_id
HGNC:17755
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti–BAFF-R IgG1 binds BAFF-R on B cells and opsonizes them, triggering Fc-mediated ADCC by NK cells/macrophages and complement-dependent cytotoxicity (CDC); BAFF signaling blockade may also promote apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor on B cells; antibody blocks BAFF/BLyS signaling and can induce ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05624749
disease_id_num_tar_ref
5497
drug_id_num_tar_ref
14962