gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds EGFR on target cells and its Fc region engages Fcγ receptor–bearing immune effectors to mediate ADCC/ADCP, leading to killing of EGFR-expressing cells (in addition to cytostatic signaling blockade/receptor downregulation).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; recognizes wild-type and certain mutant forms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06120140
disease_id_num_tar_ref
5500
drug_id_num_tar_ref
14965