gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible covalent inhibition of mutant EGFR kinase blocks downstream survival pathways (e.g., MAPK/PI3K-AKT), inducing apoptosis of EGFR-mutant tumor cells while sparing wild-type EGFR.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
L858R mutant
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06120140
disease_id_num_tar_ref
5500
drug_id_num_tar_ref
14966