gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible inhibition of mutant EGFR kinase (e.g., Exon 19 del, L858R, T790M) blocks downstream survival signaling (PI3K/AKT, MAPK), leading to growth arrest and apoptosis of EGFR-mutant tumor cells; minimal effect on wild-type EGFR.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Exon 19 deletion (Del19)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06120140
disease_id_num_tar_ref
5500
drug_id_num_tar_ref
14966