gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mosunetuzumab binds CD3 epsilon on T cells to activate them and crosslink to CD20+ B cells; the activated T cells kill CD20+ cells via perforin/granzyme. CD3+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor CD3 complex subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06249191
disease_id_num_tar_ref
5503
drug_id_num_tar_ref
14981