gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Killing requires recognition of the KRAS G12D peptide presented by HLA-A*11:01; upon peptide–MHC recognition, engineered T cells kill via perforin/granzyme (and Fas–FasL) mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-restricted presentation of KRAS G12D peptide
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06484790
disease_id_num_tar_ref
5507
drug_id_num_tar_ref
14995