gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and triggers Fc-mediated ADCC (NK cells), CDC (complement), and ADCP (macrophages), and can induce direct apoptosis of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain of CD38 (ecto-enzyme) on plasma cells and immune subsets
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06574126
disease_id_num_tar_ref
5510
drug_id_num_tar_ref
14999