gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PHN-010 binds an undisclosed tumor cell surface antigen (not topoisomerase I), is internalized, and releases a payload that inhibits topoisomerase I to induce DNA damage and apoptosis; topoisomerase I is the intracellular payload target, not the directly targeted antigen.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Likely payload target inferred from trial exclusion of prior topoisomerase I–based ADCs.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06457997
disease_id_num_tar_ref
5514
drug_id_num_tar_ref
15008