gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Affinity-enhanced TCR-T cells recognize the MAGE-A4 peptide presented by HLA-A*02 on target cells and kill them via TCR/CD3-triggered perforin/granzyme-mediated cytolysis and cytokine release.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A*02-restricted peptide presented on MHC class I
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05642455
disease_id_num_tar_ref
5517
drug_id_num_tar_ref
15012