gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
10-1074-LS binds HIV-1 Env gp120 to neutralize virus and can trigger FcγR-mediated ADCC/ADCP against Env-expressing infected cells. Its FcRn (via LS mutations) interaction only recycles IgG to extend half-life and does not kill FcRn-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
LS Fc mutations (M428L/N434S) enhance FcRn binding and extend half-life
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05300035
disease_id_num_tar_ref
466
drug_id_num_tar_ref
1302