gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the MAGE-A4 peptide presented by HLA-A*02 on target cells, activating TCR/CD3 signaling and inducing cytotoxicity via perforin/granzyme release (and Fas/FasL), leading to apoptosis.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-specific restriction element of the recognized peptide-MHC complex; HLA-A*02:05 excluded in trial
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05642455
disease_id_num_tar_ref
5517
drug_id_num_tar_ref
15012