gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CTLA-4 on intratumoral Tregs and, via its Fc-enhanced IgG1, engages Fcγ receptor–bearing effector cells (e.g., NK cells/macrophages) to mediate ADCC/ADCP (±CDC), depleting CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint receptor on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05627635
disease_id_num_tar_ref
5520
drug_id_num_tar_ref
15019