gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and its Fc engages Fcγ receptor–bearing effector cells (e.g., NK cells), triggering antibody-dependent cellular cytotoxicity and lysis of HER2+ cells; signaling blockade also inhibits growth.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of HER2; blocks dimerization and mediates ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05901935
disease_id_num_tar_ref
5526
drug_id_num_tar_ref
15040