gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor that stabilizes topo I-DNA complexes, causing DNA breaks, replication arrest, and apoptosis (with potential bystander effect).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target antigen for trastuzumab moiety (extracellular domain)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06592625
disease_id_num_tar_ref
5530
drug_id_num_tar_ref
15047