gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Small-molecule HER2 TKI that blocks HER2 autophosphorylation and PI3K/AKT/MAPK survival signaling, causing cell-cycle arrest and apoptosis of HER2-expressing tumor cells (not immune-mediated).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ATP-competitive inhibitor of HER2 kinase domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05323955
disease_id_num_tar_ref
5539
drug_id_num_tar_ref
15072