gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases the DM1 microtubule inhibitor intracellularly, causing microtubule disruption, mitotic arrest, and apoptosis (with additional Fc-mediated ADCC possible).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab moiety binds extracellular domain subdomain IV of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05323955
disease_id_num_tar_ref
5539
drug_id_num_tar_ref
15075