gene_symbol
HLA-B
hgnc_id
HGNC:4932
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs use native TCRs to recognize the tumor peptide–HLA-B complex on target cells, triggering cytotoxic T-cell killing via perforin/granzyme release and death receptor pathways (e.g., Fas–FasL).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele- and epitope-specific; polyclonal TCRs may also recognize non-mutated tumor-associated peptides
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06640582
disease_id_num_tar_ref
5540
drug_id_num_tar_ref
15076