gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs use their native TCRs to recognize tumor antigenic peptide–HLA-C complexes and directly lyse target cells via perforin/granzyme release (and Fas–FasL), with cytokine-mediated support.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele- and epitope-specific; polyclonal TCRs may also recognize non-mutated tumor-associated peptides
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06640582
disease_id_num_tar_ref
5540
drug_id_num_tar_ref
15076