gene_symbol
HLA-DRB1
hgnc_id
HGNC:4948
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize the tumor antigenic peptide–HLA-DR complex via their native TCRs and directly kill target cells through perforin/granzyme release and Fas–FasL–mediated apoptosis, with supportive cytokine effects.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized by CD4+ TILs; allele- and epitope-specific; may include mutated or non-mutated peptides
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06640582
disease_id_num_tar_ref
5540
drug_id_num_tar_ref
15076