gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes and expands neoantigen-specific CD8+ T cells; these CTLs recognize the neoantigen-HLA class I complex on tumor cells and kill them via perforin/granzyme-mediated cytolysis and Fas-FasL apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Self-replicating mRNA-encoded epitopes presented on HLA-A/B/C to CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05579275
disease_id_num_tar_ref
5556
drug_id_num_tar_ref
15122