gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on tumor cells and engages immune effector cells via its Fc region, inducing ADCC by NK cells and ADCP by macrophages (and possibly complement), leading to killing of HER2-expressing cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain 4 (subdomain IV) epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06043427
disease_id_num_tar_ref
5557
drug_id_num_tar_ref
15126