gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine primes dendritic cells to activate antigen-specific CD8+ T cells, which kill tumor cells presenting the tumor peptide on HLA-A via perforin/granzyme; HLA-A itself is not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide loading for class I presentation to CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05846516
disease_id_num_tar_ref
5560
drug_id_num_tar_ref
15136