gene_symbol
HLA-B
hgnc_id
HGNC:4932
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes tumor-specific CD8+ T cells via dendritic cell antigen presentation; CTLs then kill tumor cells presenting vaccine-encoded peptides on MHC I (e.g., HLA-B) via perforin/granzyme apoptosis. HLA-B itself is not the cytotoxic target.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide loading for CD8+ T-cell priming
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05846516
disease_id_num_tar_ref
5560
drug_id_num_tar_ref
15137