gene_symbol
HLA-DPB1
hgnc_id
HGNC:4940
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
ATP152 delivers tumor antigens to HLA-DP–expressing dendritic cells to prime CD8+/CD4+ T cells; the resulting T cells kill tumor cells presenting the antigens (primarily via MHC I), not the HLA-DP+ APCs.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide loading for CD4+ T-cell priming
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05846516
disease_id_num_tar_ref
5560
drug_id_num_tar_ref
15137