gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-GPRC5D CAR-T cells bind GPRC5D on target cells and induce cytolysis via immune synapse formation with perforin/granzyme-mediated apoptosis (and Fas/FasL).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPCR antigen on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05749133
disease_id_num_tar_ref
5565
drug_id_num_tar_ref
15153