gene_symbol
NECTIN4
hgnc_id
HGNC:19688
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds nectin-4 on target cells, is internalized, then releases MMAE via a cleavable linker; MMAE binds tubulin, inhibits microtubule polymerization, causes G2/M arrest, and induces apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface adhesion molecule targeted by the antibody for internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05775471
disease_id_num_tar_ref
5576
drug_id_num_tar_ref
15182