gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AMG 794 engages CD3 on T cells to redirect them to CLDN6+ tumor cells, triggering T-cell cytotoxicity (perforin/granzyme) against the tumor. CD3E+ T cells serve as effectors and are not the cells killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell engager arm of HLE BiTE
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05317078
disease_id_num_tar_ref
5577
drug_id_num_tar_ref
15183