gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3ε on T cells is bound by the secreted BiTE to activate and recruit T cells as effectors; these T cells (and the CAR γδ T cells) kill HLA‑G–positive tumor cells via perforin/granzyme, not the CD3+ cells themselves.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Secreted BiTE arm engages endogenous αβ T cells via CD3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06150885
disease_id_num_tar_ref
5578
drug_id_num_tar_ref
15184