gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and induces complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity (via NK cells), antibody-dependent cellular phagocytosis (via macrophages), and can trigger direct apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (ADP-ribosyl cyclase/cADPR hydrolase) on plasma cells and other immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06151717
disease_id_num_tar_ref
5579
drug_id_num_tar_ref
15185