gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The DC vaccine primes/expands neoantigen-specific T cells; these effector T cells (CD8+ and cytotoxic CD4+) recognize neoantigen–HLA complexes on tumor cells and kill them via perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented on HLA-DR/DQ/DP to CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06752057
disease_id_num_tar_ref
470
drug_id_num_tar_ref
1310