gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binding to transmembrane TNF enables IgG1 Fc–mediated ADCC and complement-dependent cytotoxicity against TNF-expressing cells, and can induce apoptosis via reverse signaling through membrane TNF.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds transmembrane TNF (tmTNF); can mediate ADCC/CDC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05906576
disease_id_num_tar_ref
5580
drug_id_num_tar_ref
15189