gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize CD19 on target cells; CAR signaling triggers T-cell degranulation with perforin/granzyme and death receptor pathways, inducing apoptosis of CD19-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell lineage surface antigen; common target of approved CAR T therapies in B-cell malignancies
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05643092
disease_id_num_tar_ref
5590
drug_id_num_tar_ref
15210