gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-targeted CAR T cells bind BCMA on target cells, triggering CD3ΞΆ/costimulatory signaling and directly killing BCMA+ cells via perforin/granzyme-mediated cytolysis (and Fas/FasL apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Plasma cell surface receptor; common target of approved CAR T therapies in multiple myeloma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05643092
disease_id_num_tar_ref
5590
drug_id_num_tar_ref
15210