gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize HBV peptide–HLA-A*02:01 complexes on tumor cells, become activated, and kill them via cytotoxic T-cell effector mechanisms (perforin/granzyme release and Fas–FasL–mediated apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
pMHC-I complex on HBV-related hepatocellular carcinoma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06961617
disease_id_num_tar_ref
5599
drug_id_num_tar_ref
15233