gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the HBV peptide–HLA-A*24:02 complex via their TCR, leading to MHC I–dependent activation and killing of target cells through perforin/granzyme (and Fas–FasL) cytotoxic pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
pMHC-I; peptide source: HBV antigens (exact epitope unspecified)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06961617
disease_id_num_tar_ref
5599
drug_id_num_tar_ref
15234