gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific antibody bridges PD-1+ T cells to HER2+ tumor cells and blocks PD-1, enabling focused T‑cell–mediated killing (immune synapse formation and perforin/granzyme cytotoxicity).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06390774
disease_id_num_tar_ref
5603
drug_id_num_tar_ref
15243