gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells and recruits Fcγ receptor–bearing effector cells (e.g., NK cells) to mediate antibody-dependent cellular cytotoxicity (ADCC), killing HER2+ cells; it also inhibits HER2 signaling, promoting apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds domain IV of the HER2 extracellular region; IgG1 Fc mediates ADCC via Fcγ receptors on effector cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06441890
disease_id_num_tar_ref
5618
drug_id_num_tar_ref
15284