gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on tumor cells and engages Fcγ receptors on immune effectors to trigger ADCC; blockade of HER2/HER3 signaling also promotes apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain II (dimerization arm); blocks HER2/HER3 dimerization and downstream signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06441890
disease_id_num_tar_ref
5618
drug_id_num_tar_ref
15285