gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on tumor cells; its Fc engages CD16a on NK cells to trigger ADCC, resulting in NK-mediated killing of HER2+ cells. CD16a-expressing immune cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc engagement mediating ADCC on NK cells/effector leukocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06441890
disease_id_num_tar_ref
5618
drug_id_num_tar_ref
15285