gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
R-TM123 bridges CD123 on target cells to the RevCAR on engineered T cells, activating CAR signaling and T cell–mediated killing (perforin/granzyme apoptosis) of CD123+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Adapter-mediated via bispecific R-TM123 bridging
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05949125
disease_id_num_tar_ref
5621
drug_id_num_tar_ref
15288