gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and engages Fcγ receptors on immune effectors to trigger antibody‑dependent cellular cytotoxicity (ADCC), killing HER2+ cells; it also inhibits HER2 signaling, which can promote apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain, primarily subdomain IV
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05187182
disease_id_num_tar_ref
5625
drug_id_num_tar_ref
15302