gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP-2, is internalized, and releases SN-38 via linker cleavage; SN-38 inhibits topoisomerase I, causing DNA damage and apoptosis (with possible bystander killing from extracellular SN-38).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycoprotein; antibody binding mediates internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07018427
disease_id_num_tar_ref
5628
drug_id_num_tar_ref
15312