gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
PSMA-binding radioligand is internalized and delivers Lu-177 beta-particle radiation, causing DNA double-strand breaks and death of PSMA-expressing cells (with short-range bystander/crossfire effects).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glutamate carboxypeptidase II; ligand binding leads to internalization and localized beta radiation delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05766371
disease_id_num_tar_ref
5633
drug_id_num_tar_ref
15320