gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Not targeted. The CAR recognizes TM4SF1, not EGFR. EGFR is included only as a safety tag on the CAR T cells for their ablation by anti‑EGFR therapy; EGFR+ host cells are not killed by the CAR T product.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
truncated EGFR safety-switch tag on CAR T cells enabling depletion with anti-EGFR antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05673434
disease_id_num_tar_ref
5636
drug_id_num_tar_ref
15326